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Pusch W, Wurmbach JH, Thiele H, Kostrzewa M

While GLP-1 receptors are expressed primarily in pancreatic beta cells, the gastrointestinal tract, and certain areas of the central nervous system, the expression and function of these receptors in joint tissues is not well characterized

While cardiovascular outcome data for retatrutide is still accumulating, the prudent approach for anyone with active cardiovascular disease is to remain on compounds with established cardiovascular safety profiles

It usually affects females and starts during the first two decades of life

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